Sarcopenia, the decreasing of muscle leading to weakness and frailty due to aging, independent of obesity, was associated with adverse glucose metabolism, strongest in individuals under 60 years of age, which suggests low muscle mass may be an early predictor of diabetes susceptibility, according to researchers at UCLA (PLoS ONE. 2010;5(5):e10805). A cross-sectional analysis of National Health and Nutrition Examination Survey III data, utilizing non-pregnant subjects of 20 years or older, (n=14,528) was performed. Sarcopenia was identified from bioelectrical impedance measurement of muscle mass. Obesity was identified from body mass index (BMI).
Sarcopenia was associated with insulin resistance in non-obese and obese individuals. Sarcopenia was associated with dysglycemia in obese individuals but not in non-obese individuals. Associations were stronger in those under 60 years of age. Researchers acknowledged the cross-sectional study design limited their ability to draw causal inferences.
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