Orally Disintegrating Tablets

Continued from Yesterday

Common Types of ODTs

The two main forms of ODTs are freeze-dried formulations and loosely compressed tablets. Some industry members define a third delivery form as oral thin-film strip products such as Chloraseptic Relief Strips and Listerine Pocket Paks; however, as these formats are not tablets, they are not discussed in this article.

The most successful commercial ODT freeze drying manufacturing technology is the Zydis process, which was the first patented ODT technology to market. This tablet dissolves in the mouth within seconds after placement on the tongue. A Zydis tablet is produced by preparing an aqueous drug solution or suspension in bulk, dosing it into preformed blister packs and then cryogenically freezing it to ensure development of porous material. Next, the blister packs are moved to freeze dryers where most of the water is removed from the tablets. Last, the blister packs are heat-sealed to ensure stability.

This process results in a highly porous structure, which increases quick dissolution. Advantages include rapid dissolution, self-preservation from microbial growth and increased bioavailability. The main drawback is higher cost, due in part to a more time-consuming manufacturing process. Additionally, these tablets can have poor stability at high temperature and humidity conditions. Furthermore, these tablets are more fragile than others and must be packaged in special blister packs to prevent mechanical and moisture damage. Other technologies using freeze-drying techniques are Lyoc and QuickSolv.

Continued Tomorrow

http://www.naturalproductsinsider.com/articles/2011/04/orally-disintegrating-tablets-a-quick-overview.aspx

http://www.depsyl.com/

http://back2basicnutrition.com/

http://bionutritionalresearch.olhblogspace.com/