Orally Disintegrating Tablets

Orally Disintegrating Tablets: A Quick Overview

Orally disintegrating tablets (ODTs) are a popular delivery form found in many prescription, over-the-counter (OTC) medicines and dietary supplements. These technologies are often referred to as melt-in-mouth, rapimelt, rapid disintegrating, orodispersible, quick dissolving or porous tablets, not to be confused with chewable tablets that require chewing and swallowing.

FDA’s Center for Drug Evaluation and Research (CDER) defines an ODT as “a solid dosage form containing medicinal substances, which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue.”1 Examples of well-known ODTs are Jr. Tylenol Meltaways, Benedryl Fastmelts and Claritin Ready Tabs.

Because ODT’s dissolve in the mouth with saliva, they release the active drugs in pregastric, gastric and postgastric phases of the gastrointestinal (GI) system. On the contrary, conventional tablets must be swallowed with water for dissolution, released, and absorbed in the stomach and postgastric sites of the GI system.

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http://www.naturalproductsinsider.com/articles/2011/04/orally-disintegrating-tablets-a-quick-overview.aspx

http://www.depsyl.com/

http://back2basicnutrition.com/

http://bionutritionalresearch.olhblogspace.com/