Tuesday, April 26, 2011

Olive Oil Compound and Alzheimer's

Oleocanthal, a compound in extra-virgin olive oil, may alter the state of a protein involved in Alzheimer's disease, according to a recent study published in Toxicology and Applied Pharmacology.

A[beta]-derived diffusible ligands (ADDLs) are small proteins that have been shown to stick to synapses in the nervous system, thereby impairing nerve cell function.

In the study, oleocanthal altered the structure of ADDLs in such a way that they were unable to stick to synapses. However, these results are still preliminary and further research is warranted before conclusions can be made.

Other integrative therapies have been studied as potential treatment or prevention strategies. For instance, strong evidence supports the use of ginkgo fro multi-infarct dementia and Alzheimer's-type dementia. Strong evidence also supports the use of sage for cognitive improvement.

For more information about Alzheimer's disease, please visit Natural Standard's Medical Conditions database.


1.Natural Standard: The Authority on Integrative Medicine.

2.Pitt J, Roth W, Lacor P, et al. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol. 2009 Oct 15;240(2):189-97. View Abstract

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