What Makes People Obese?

Molecule That Makes Obese People Develop Diabetes Discovered

A new European study has shown that obese people have large amounts of the chemokine molecule CXCL5, produced by certain cells in fatty tissue, and it is this molecule that researchers feel will cause an obese person to develop Type II Diabetes.

'Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistance and Type II Diabetes", Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, said.

Serum levels of CXCL5, produced by certain adipose tissue cells, appear at much high levels in the tissues of obese people than in those of individuals with normal weight. An experimental treatment aimed at inhibiting the action of CXCL5 has protected obese mice from developing Type II Diabetes. If this can be shown in humans, an important step to prevent diabetes in obese people will have been taken.

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