Chien-yi [Qian Yi; ca. 1032-1113 A.D.] - Qian specialized in treatment of children and wrote the famous book Xiaoer Yaozheng Zhijue (Key to Therapeutics of Children's Diseases). This book presented the prescription Rehmannia Six Formula (Liuwei Dihuang Wan), which has become the most widely used yin-nourishing prescription, especially given to the elderly despite its origins as a pediatric formulation.
Rehmannia Six Formula (Liuwei Dihuang Wan) is one of the most commonly used Chinese herb formulas in the world. It serves as a stand-alone remedy, as a base formula from which to make numerous modifications (mostly by additions, occasionally one or two herbs are deleted when others are added), and as an adjunct to other formulas. The fact of its wide-spread use, given the limited scope of application when it was first described, is itself a reasonable subject of investigation. There must be certain properties of the herbs and valuable aspects of the formulation principles that lend to such flexibility in its use.
http://www.itmonline.org/docs/chienyi.htm
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