High-Fat Foods Intensify Asthma

Individuals with asthma should avoid eating high-fat foods because they cause increased airway inflammation and may inhibit the response to the asthma reliever medication Ventolin (albuterol), according to a new study presented at the ATS 2010 International Conference.

“Subjects who had consumed the high-fat meal had an increase in airway neutrophils and TLR4 mRNA gene expression from sputum cells, that didn’t occur following the low-fat meal,” said Dr. Lisa Wood, PhD, research fellow of the University of Newcastle. “The high-fat meal impaired the asthmatic response to albuterol. In subjects who had consumed a high-fat meal, the post-albuterol improvement in lung function at three and four hours was suppressed.”

Researchers studied 40 asthmatic subjects who were randomized to receive either a high-fat, high-calorie “food challenge”, consisting of fast-food burgers and hash browns containing about 1,000 calories, 52 percent of which were from fat; or a low-fat, low-calorie meal consisting of reduced-fat yogurt, containing about 200 calories, and 13 percent fat.

Sputum samples were collected before the meal and four hours afterward, and analyzed for inflammatory markers. Subjects who had consumed the high-fat meal had a marked increase in airway neutrophils and TLR4 mRNA gene expression. Subjects who had consumed the high-fat meal also had reduced bronchodilator response as measured by FEV1% predicted and FEV1/FVC%, when compared to those had consumed the low-fat meal.


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