What the Story Behind Preventing Type 2 Diabetes? #4

Continued from Yesterday

Chinese Diabetes Prevention Study-The Da Qing IGT and Diabetes Study

The National Diabetes Data Group recognized the classification of IGT in 1979 due to evidence that it was associated with a higher incidence of diabetes and was associated ¡with obesity, hypertension, hyperlipidemia, and an increased risk of cardiovascular disease (National Diabetes Data Group 1979). In 1986, the Da Qing IGT and Diabetes Study began in Da Qing, Chia. Baseline data revealed that those with IGT were twice as likely to have hypertension, obesity, and abnormal urar albumin excretion as those with normal glucose tolerance. Plasma cholesterol and trglycerides were higher and high-density lipoprotein (HDL) cholesterol lower in subjects with IGT. Subjects with IGT had higher plasma insulin concentrations but lower insulin-to-glucose ratio at 1 h after a 75 g glucose load. The prevalence of electrocardiographically recognized coronary hear disease was 9.5-fold greater in IGT, and IGT remained an independent coronary hear disease risk factor after adjusting for confounders (pan et al. 1993).

In the Da Qing IGT and Diabetes Study, subjects with IGT were randomized to one of four groups by clinic: (1) control, (2) diet alone, (3) exercise alone, and (4) diet plus exercise. Subjects were approximately 45 years of age, with a mean BMI of 26 kg/m2 and both genders were represented.

It appeared that either deit or exercise reduced conversion of IGT to diabetes, but combining them was not more effective than using either one separately. The interventions were more effective in those with less insulin resistance.

Continued Tomorrow

Source: Nutraceuticals, Glycemic Health and Type 2 Diabetes
Frank Greenway, MD
Chapter 3

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