Showing posts with label Diabetes; Metabolic Disorders;. Show all posts
Showing posts with label Diabetes; Metabolic Disorders;. Show all posts
Friday, April 29, 2011
What is Metabolomics?
Metabolomics Part 2:
Shelf-Life, Tracking, Sourcing & Purity
A look at how metabolomics can be used as a tool in the future of food quality improvements.
A continuation of a three part series, this second article will delve into cases for the use of metabolomics, a technology used to detect small molecules such as amino acids, organic acids, sugars, volatile metabolites and secondary metabolites such as alkaloids, phenolic components and also pigments such as carotenoids and anthocyanins present in food and food ingredients.
Case 1: Metabolomics and Shelf-Life Prediction
Reliable shelf-life determination and labeling is hugely important but is also hugely difficult. Too short times means losing potential business and increased wastage while too long can result in risking retailer trust and consumer preference in the long term. Erring on the side of caution is the norm. Having a better understanding of the processes involved in product deterioration and the factors influencing it would clearly provide us with a better model for shelf-life prediction. Such an improved understanding, together with a means to compensate for batch-related differences caused by unknown or invisible product pre-history (environmental perturbations, on-farm cultivation practices, sub-optimal transportation and storage, etc.) will enable more accurate and reliable determination of shelf life labeling.
In the META-PHOR project for example, metabolomics approaches were used to follow product deterioration under supermarket-identical conditions. Looking at both fresh melon and broccoli samples it could be shown that the transition between acceptable/suboptimal quality is remarkably sharp and the development of a lower quality product (containing e.g. off-flavors, showing color changes etc) occurs over a short period. What industry needs are quality/shelf-life predictors—so called "biomarkers" that are already present in the raw materials upon entering the factory. These biomarkers may represent either positive or negative attributes and as these are currently unknown molecules with unpredictable function, metabolomics would seem the most valuable approach to choose for their identification. However, once identified, metabolomics may no longer need to be used as the aim is to exploit subsequently the biomarkers in a simple kind of “predictor/dip-stick” type of test more suited to an industrial environment requiring cheap and rapid results on-site.
http://www.nutraceuticalsworld.com/contents/view/32614
http://www.depsyl.com/
http://back2basicnutrition.com/
http://bionutritionalresearch.olhblogspace.com/
Thursday, April 28, 2011
What is Metabolomics?
Continued from Yesterday
Improved Crops as Sources of Healthier Foods
Most of what we eat on a global scale is plant-based—in some cultures, exclusively so. Crop plants and their products therefore are hugely important to human health through their contribution to our daily diet. At all points in the crop production chain—from breeder to supermarket—there is a demand for better products and metabolomics has the potential to help us achieve this.
Metabolomics will help us define in greater detail what exactly we are eating and how this is influenced. Metabolomics will also help us identify key biomarkers naturally present that we need in order to understand and monitor the interaction between food intake/uptake and human health. With such knowledge we will then be in a better position to design food production systems better suited to modern dietary needs.
Metabolomics is predicted to become a cornerstone in this field and will be exploited to advance breeding strategies and generate foodstuffs with optimal nutritional composition and meeting consumer quality desires. Furthermore, the food industry is continually in search of improved processing strategies to maintain quality, reduce loss and extend shelf life/stability. Metabolomics has a role to play here also and while the technology is still in a phase of development, applications are already in place.
The next installment of this article, will present three cases for the use of metabolomics. Please check back on Monday, April 25 for the second part of this three part series.
About the author: Gerard Klein Essink, MSc, is managing director of Bridge2Food in The Netherlands, and Dr. Robert D. Hall is managing director of Centre for BioSystems Genomics CBSG2012, Plant Research International, also in The Netherlands.
http://www.nutraceuticalsworld.com/contents/view/32539
http://www.depsyl.com/
http://back2basicnutrition.com/
http://bionutritionalresearch.olhblogspace.com/
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